朱智瑋

Elucidating the Molecular Impact of TREX1 Inhibitors via Molecular Dynamics Simulations

智慧醫電工程研究所

Three-Prime Repair Exonuclease 1 (TREX1)、分子動力學模擬、小分子抑制劑、內在無結構區域 (IDR)、異位調節、藥物設計、Molecular Dynamics Simulation、Small-molecule Inhibitors、Intrinsically Disordered Region (IDR)、Allosteric Regulation、Drug Design

Computational Studies on the Binding Mechanisms of TREX1 with Double-Stranded DNA, Double-Stranded RNA, and Hybrid Duplex by Molecular Dynamics Simulations

工程與計算生醫產業碩士專班

三端修飾外切酶 1(Three prime Repair Exonuclease 1、TREX1)、DEDDh 活 性中心、金屬依賴性催化核心、分子動力學模擬、DNA/RNA 混成受質、氫鍵作用、Three-Prime Repair Exonuclease 1 (TREX1)、DEDDh active site、metal-dependent catalytic core、molecular dynamics (MD) simulation、DNA/RNA hybrid、Hydrogen bonding

Linear Analysis of Drug Vector Spaces and Correlation with Physical Chemical Properties: A Comparative Study of Descriptors and Identifier Vector

生物資訊及系統生物研究所

電腦輔助藥物設計、分子結構表示法、結構描述符、標識符、物理化學性質、奇異值分解、Computer-Aided Drug Design、Molecular representation、Structural descriptor、Identifier、Physicochemical properties、Singular value decomposition

Mechanical Properties of Human Telomeric G-quadruplex Revealed by Structure-mechanics Statistical Learning

生物資訊及系統生物研究所

G 四聯體、分子動力學模擬、藥物設計、統計/機器學習、圖論、G-quadruplex、molecular dynamics simulation、drug design、statistical machine learning、graph theory

Analysis of TREX2 Protein Dynamics and the Impact on Substrate and Inhibitor Binding

生物科技學系

TREX2、分子動力學模擬、系綜構型、模擬嵌合、molecular simulation、binding affinity、ensemble docking

Deciphering Nucleic Acid Mechanics by Structure-Mechanics Statistical Learning

生物資訊及系統生物研究所

核酸力學、遺傳密碼、轉錄、統計/機器學習、圖論、DNA mechanics、mechanical code、transcription、statistical machine learning、graph theory

Statistical Learning of Elastic Network Model for Bridging Protein Dynamics and Homologous Structures

生物資訊及系統生物研究所

分子動態模擬、同源蛋白質結構、多重序列比對、統計學習、敏感度分析、Molecular dynamics simulation、Homologous protein structure、Multiple sequence alignment、Statistical learning、Sensitivity analysis

Using Molecular Dynamics Simulation to Analyze the Structural Changes of APE1 Substrate Binding and the Mechanism of AP Site Recognition

生物資訊及系統生物研究所

脫嘌呤/脫嘧啶核酸內切酶 1 (APE1)、DNA損傷、鹼基刪除修復、分子動態模擬、RM bridge、Apurinic/apyrimidinic endonuclease1 (APE1)、DNA damage、base excision repair、molecular dynamics simulation

Molecular Dynamics Simulation Studies on the Structural and Mechanical Effects of Methylated CpG Sequences

生物資訊及系統生物研究所

雙螺旋去氧核醣核酸、CpG島、DNA甲基化、五碳糖褶皺構型、分子動態模擬、double strand DNA、CpG island、DNA methylation、sugar pucker conformation、molecular dynamics simulation

Elucidation of the Molecular Mechanism in Protein Functional Properties by Structure-Mechanics Statistical Learning

生物資訊及系統生物研究所

大鼠胰蛋白酶、PDZ3結構域、分子動態模擬、統計學習、圖論、Rat trypsin、PDZ3、Molecular dynamics、Statistical learning、Scale-free

Using Molecular Dynamics Simulation to Unravel theInhibition Mechanism of PCMPS on NP Exonuclease

生物資訊及系統生物研究所

拉薩熱病毒、核蛋白核酸外切酶、對氯汞苯磺酸、分子動力學模擬、異位效應、Lassa fever virus、NP Exonuclease、PCMPS、molecular dynamics simulation、allosteric effect

Using Molecular Simulation to Study the Effects of Methylation on the Structural and Mechanical properties of Double-Stranded Nucleic Acid

生物資訊及系統生物研究所

DNA、甲基化、DNA甲基化、methylation、DNA merhylation

Using Molecular Dynamics Simulation to Study the Structural and Mechanical Roles of the Intrinsically Disordered C-terminal Domain in Escherichia coli Single-Stranded DNA-Binding Protein (SSB)

分子醫學與生物工程研究所

單鏈DNA結合蛋白、單股DNA、固有無序鏈結分子、分子動態模擬、Single-Stranded DNA-Binding Protein、ssDNA、Intrinsically Disordered Linker、Molecular Dynamics Simulation

Using Molecular Simulation to Study the Structural Variation of TtAgo upon Binding to Different Substrates

生物資訊及系統生物研究所

分子動力學、結構變化、Argonaute、Quasi-harmonic analysis

Molecular Simulation Studies for the Effects of Inhibitor PCMPS on the Conformational Dynamics of Exonuclease

生物資訊及系統生物研究所

核酸外切酶、拉薩病毒、分子動態模擬、exonuclease、Lassa virus、dynamic simulation

Understanding Biological Oscillator through Computational Model: The Study of Arabidopsis Circadian Clock

生物資訊及系統生物研究所・共同指導：許昭萍

系統生物學、生理時鐘、雙穩態、非相干前饋迴路、數學模型、System Biology、Circadian Clock、Bistability、Incoherent feed-forward loop、Mathematical model

On the Mechanical Couplings in dsDNA, dsRNA, and Hybrid Duplexes via Multiscale Molecular Simulation

生物資訊及系統生物研究所

雙股核糖核酸、雙股去氧核醣核酸、分子模擬、Nucleic acids、DNA、RNA、Molecular simulation